Editing of Epstein-Barr virus-encoded BART6 microRNAs controls their dicer targeting and consequently affects viral latency

Journal of Biological Chemistry · October 2010

Iizasa H, Wulff B-E, Alla NR, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A, Showe L, Lieberman P, Nishikura K

Summary

This study shows that adenosine-to-inosine editing of Epstein-Barr virus BART6 miRNAs alters their recognition by Dicer, leading to changes in miRNA processing and abundance. The editing events modulate viral latency, linking RNA editing to EBV biology.

Summary#

Summary