Brain

Summary This study combines single-cell analysis with long-read nanopore sequencing to capture full-length RNA isoforms and uncover temporal changes in RNA transcription, processing, and alternative splicing in the aging mouse cortex and hippocampus.

Summary Spatial transcriptomics profiling of the aging mouse brain reveals that inflammatory gene expression changes during aging are not uniformly distributed but originate preferentially in white matter regions. The findings provide a spatially resolved map of the aging brain transcriptome and identify candidate cellular drivers of neuroinflammation.