Brain on Maragkakis Labhttp://maragkakislab.com/tags/brain/Recent content in Brain on Maragkakis LabHugoen-usSun, 08 Jun 2025 00:00:00 +0000Cell-specific RNA isoform remodeling in the aging mouse brainhttp://maragkakislab.com/publications/2025-rna-isoform-aging-brain/Sun, 08 Jun 2025 00:00:00 +0000http://maragkakislab.com/publications/2025-rna-isoform-aging-brain/<h2 id="summary">Summary</h2> <p>This study combines single-cell analysis with long-read nanopore sequencing to capture full-length RNA isoforms and uncover temporal changes in RNA transcription, processing, and alternative splicing in the aging mouse cortex and hippocampus.</p>Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matterhttp://maragkakislab.com/publications/2025-spatial-transcriptomics-aging-brain/Fri, 04 Apr 2025 00:00:00 +0000http://maragkakislab.com/publications/2025-spatial-transcriptomics-aging-brain/<h2 id="summary">Summary</h2> <p>Spatial transcriptomics profiling of the aging mouse brain reveals that inflammatory gene expression changes during aging are not uniformly distributed but originate preferentially in white matter regions. The findings provide a spatially resolved map of the aging brain transcriptome and identify candidate cellular drivers of neuroinflammation.</p>