CD19 on Maragkakis Labhttp://maragkakislab.com/tags/cd19/Recent content in CD19 on Maragkakis LabHugoen-usWed, 01 Apr 2020 00:00:00 +0000Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19http://maragkakislab.com/publications/2020-cd19-cart19-resistance/Wed, 01 Apr 2020 00:00:00 +0000http://maragkakislab.com/publications/2020-cd19-cart19-resistance/<h2 id="summary">Summary</h2> <p>This study identifies intron 2 retention in CD19 transcripts as a mechanism contributing to CAR-T19 therapy resistance in leukemias harboring subclonal frameshift mutations in CD19. The findings reveal how alternative splicing can undermine antigen-targeted cancer immunotherapy.</p>