Cellular Stress on Maragkakis Lab

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

Thu, 19 Dec 2024 00:00:00 +0000

Summary

Using full-length direct RNA sequencing, this study uncovers a previously unrecognized role for stress granules in promoting selective mRNA decay during cellular stress. The findings show that mRNAs recruited to stress granules undergo preferential degradation, linking stress granule biology to RNA homeostasis.

Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype

Thu, 21 Nov 2024 00:00:00 +0000

Summary

This study reveals that senescent cells suppress the canonical integrated stress response (ISR) while activating a remodeled secretory program. The suppression of ISR in senescence is mechanistically linked to altered eIF2α phosphorylation dynamics, and the resulting secretory phenotype differs from the classical SASP, with implications for age-related tissue dysfunction.

RNA-mediated control of protein translation under stress

Thu, 20 Jul 2023 00:00:00 +0000

Summary

This review covers the post-transcriptional mechanisms by which cells regulate protein synthesis in response to stress, focusing on the roles of RNA-binding proteins, non-coding RNAs, and mRNA modifications in controlling translation. The connections between stress-responsive translational control and aging are discussed.

Biology of Stress Responses in Aging

Tue, 27 Jun 2023 00:00:00 +0000

Summary

This review covers the major cellular stress response pathways and how they are altered during aging. Topics include the integrated stress response, heat shock response, oxidative stress, proteostasis, and their connections to age-associated physiological decline and disease.