Deep Learning on Maragkakis Labhttp://maragkakislab.com/tags/deep-learning/Recent content in Deep Learning on Maragkakis LabHugoen-usSun, 29 Sep 2024 00:00:00 +0000Deep learning and direct sequencing of labeled RNA captures transcriptome dynamicshttp://maragkakislab.com/publications/2024-rnakinet/Sun, 29 Sep 2024 00:00:00 +0000http://maragkakislab.com/publications/2024-rnakinet/<h2 id="summary">Summary</h2> <p>We developed RNAkinet, a neural network that identifies newly synthesized RNA molecules labeled with 5-ethynyl uridine (5EU) using nanopore direct RNA sequencing, processing raw electrical signals without requiring basecalling or sequence alignment. RNAkinet enables simultaneous analysis of RNA metabolism alongside poly(A) tail length and RNA modifications at single-molecule resolution.</p>