Summary This study dissects the molecular interactions between Aubergine and Tudor-domain proteins and their roles in piRNA amplification through the ping-pong cycle and in the formation of the germ plasm. The findings provide mechanistic insight into how piRNA pathway components are organized in germ granules.
Summary This study characterizes the small RNA content of the Drosophila Kc167 cell line and demonstrates that it contains an active primary piRNA pathway. The findings establish Kc167 cells as a useful model system for studying piRNA biogenesis and function in vitro.
Summary This update to the DIANA-microT web server extends its target prediction capabilities to Drosophila melanogaster and Caenorhabditis elegans microRNAs, and introduces a bibliographic module linking microRNAs to diseases based on the scientific literature.