Epigenomics on Maragkakis Labhttp://maragkakislab.com/tags/epigenomics/Recent content in Epigenomics on Maragkakis LabHugoen-usMon, 01 Jun 2026 00:00:00 +0000SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent primary cell typeshttp://maragkakislab.com/publications/2026-sencat/Mon, 01 Jun 2026 00:00:00 +0000http://maragkakislab.com/publications/2026-sencat/<h2 id="summary">Summary</h2> <p>SenCat is a comprehensive multiomic atlas of human cell senescence generated by profiling multiple primary cell types induced to senescence through distinct triggers. Integrated analysis of transcriptome, epigenome, and proteome data across cell types and senescence inducers redefines the core features of the senescent state and identifies cell-type-specific and universal senescence signatures.</p>Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aginghttp://maragkakislab.com/publications/2024-dna-hydroxymethylation-aging/Sun, 28 Jul 2024 00:00:00 +0000http://maragkakislab.com/publications/2024-dna-hydroxymethylation-aging/<h2 id="summary">Summary</h2> <p>This study reveals that 5-hydroxymethylcytosine (5hmC) enrichment in gene bodies acts as an epigenetic mechanism that constrains the amplitude of transcriptional changes occurring during aging. Genes with high 5hmC show attenuated age-related expression changes, identifying DNA hydroxymethylation as a regulator of transcriptional stability in aging tissues.</p>