Integrated Stress Response

Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype

Summary This study reveals that senescent cells suppress the canonical integrated stress response (ISR) while activating a remodeled secretory program. The suppression of ISR in senescence is mechanistically linked to altered eIF2α phosphorylation dynamics, and the resulting secretory phenotype differs from the classical SASP, with implications for age-related tissue dysfunction.

RNA-mediated control of protein translation under stress

Summary This review covers the post-transcriptional mechanisms by which cells regulate protein synthesis in response to stress, focusing on the roles of RNA-binding proteins, non-coding RNAs, and mRNA modifications in controlling translation. The connections between stress-responsive translational control and aging are discussed.