Integrated Stress Response on Maragkakis Labhttp://maragkakislab.com/tags/integrated-stress-response/Recent content in Integrated Stress Response on Maragkakis LabHugoen-usThu, 21 Nov 2024 00:00:00 +0000Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotypehttp://maragkakislab.com/publications/2024-senescence-stress-response/Thu, 21 Nov 2024 00:00:00 +0000http://maragkakislab.com/publications/2024-senescence-stress-response/<h2 id="summary">Summary</h2> <p>This study reveals that senescent cells suppress the canonical integrated stress response (ISR) while activating a remodeled secretory program. The suppression of ISR in senescence is mechanistically linked to altered eIF2α phosphorylation dynamics, and the resulting secretory phenotype differs from the classical SASP, with implications for age-related tissue dysfunction.</p>RNA-mediated control of protein translation under stresshttp://maragkakislab.com/publications/2023-rna-protein-translation-stress/Thu, 20 Jul 2023 00:00:00 +0000http://maragkakislab.com/publications/2023-rna-protein-translation-stress/<h2 id="summary">Summary</h2> <p>This review covers the post-transcriptional mechanisms by which cells regulate protein synthesis in response to stress, focusing on the roles of RNA-binding proteins, non-coding RNAs, and mRNA modifications in controlling translation. The connections between stress-responsive translational control and aging are discussed.</p>