Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

Wed, 11 Jun 2025 00:00:00 +0000

Summary

Using iPSC-derived neurons and cerebral organoids, this study demonstrates that viral infections — including HSV-1 and tick-borne encephalitis virus — activate Alzheimer’s disease-related pathways and induce cellular senescence. The findings support a causal link between viral infection and neurodegeneration, suggesting that vaccination-based prevention of viral infections may reduce Alzheimer’s disease risk.

IPSC on Maragkakis Lab

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

Summary