Mitochondria

Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Summary This study shows that disease-associated FUS mutations cause mitochondrial shortening and fragmentation in neurons, leading to neurotoxicity. The findings connect FUS dysfunction to mitochondrial dynamics, providing a potential mechanism for neurodegeneration in ALS patients carrying FUS mutations.

Mitochondrial protein BmPAPI modulates the length of mature piRNAs

Summary This study identifies BmPAPI, a mitochondrial protein in the silkworm Bombyx mori, as a factor that modulates the length of mature piRNAs. The findings provide mechanistic insight into the piRNA 3’ end processing pathway and link mitochondria to piRNA biogenesis.