Mitochondria on Maragkakis Labhttp://maragkakislab.com/tags/mitochondria/Recent content in Mitochondria on Maragkakis LabHugoen-usMon, 22 Oct 2018 00:00:00 +0000Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicityhttp://maragkakislab.com/publications/2018-als-fus-mitochondria/Mon, 22 Oct 2018 00:00:00 +0000http://maragkakislab.com/publications/2018-als-fus-mitochondria/<h2 id="summary">Summary</h2> <p>This study shows that disease-associated FUS mutations cause mitochondrial shortening and fragmentation in neurons, leading to neurotoxicity. The findings connect FUS dysfunction to mitochondrial dynamics, providing a potential mechanism for neurodegeneration in ALS patients carrying FUS mutations.</p>Mitochondrial protein BmPAPI modulates the length of mature piRNAshttp://maragkakislab.com/publications/2013-bmpapi-pirna-length/Tue, 01 Oct 2013 00:00:00 +0000http://maragkakislab.com/publications/2013-bmpapi-pirna-length/<h2 id="summary">Summary</h2> <p>This study identifies BmPAPI, a mitochondrial protein in the silkworm Bombyx mori, as a factor that modulates the length of mature piRNAs. The findings provide mechanistic insight into the piRNA 3&rsquo; end processing pathway and link mitochondria to piRNA biogenesis.</p>