Retrotransposons on Maragkakis Labhttp://maragkakislab.com/tags/retrotransposons/Recent content in Retrotransposons on Maragkakis LabHugoen-usMon, 01 May 2023 00:00:00 +0000The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in micehttp://maragkakislab.com/publications/2023-mov10-line1-restriction/Mon, 01 May 2023 00:00:00 +0000http://maragkakislab.com/publications/2023-mov10-line1-restriction/<h2 id="summary">Summary</h2> <p>This study shows that MOV10, an RNA helicase with roles in the piRNA pathway, acts as a dosage-dependent restriction factor for LINE1 retrotransposons in mice. Reduction of MOV10 levels leads to increased LINE1 retrotransposition, implicating MOV10 in genome defense against mobile elements.</p>