Review

Summary This review examines the evidence for senescence in vascular smooth muscle cells (VSMCs) and its contribution to vascular aging and disease. The authors discuss the mechanisms driving VSMC senescence, its downstream consequences for vascular function, and the potential for senolytic and senomorphic interventions.

Summary This review covers the major cellular stress response pathways and how they are altered during aging. Topics include the integrated stress response, heat shock response, oxidative stress, proteostasis, and their connections to age-associated physiological decline and disease.