Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis
Summary This study discovers ribothrypsis, a previously unknown mRNA decay process in which ribosomes trigger endonucleolytic cleavage of mRNAs in a ribosome-phased pattern. Ribothrypsis operates during active translation and represents a major pathway of canonical mRNA decay in human cells.