Ribosomes on Maragkakis Labhttp://maragkakislab.com/tags/ribosomes/Recent content in Ribosomes on Maragkakis LabHugoen-usSun, 01 Apr 2018 00:00:00 +0000Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysishttp://maragkakislab.com/publications/2018-ribothrypsis/Sun, 01 Apr 2018 00:00:00 +0000http://maragkakislab.com/publications/2018-ribothrypsis/<h2 id="summary">Summary</h2> <p>This study discovers ribothrypsis, a previously unknown mRNA decay process in which ribosomes trigger endonucleolytic cleavage of mRNAs in a ribosome-phased pattern. Ribothrypsis operates during active translation and represents a major pathway of canonical mRNA decay in human cells.</p>