RNA Decay

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

Summary Using full-length direct RNA sequencing, this study uncovers a previously unrecognized role for stress granules in promoting selective mRNA decay during cellular stress. The findings show that mRNAs recruited to stress granules undergo preferential degradation, linking stress granule biology to RNA homeostasis.

Ribothrypsis, a novel process of canonical mRNA decay, mediates ribosome-phased mRNA endonucleolysis

Summary This study discovers ribothrypsis, a previously unknown mRNA decay process in which ribosomes trigger endonucleolytic cleavage of mRNAs in a ribosome-phased pattern. Ribothrypsis operates during active translation and represents a major pathway of canonical mRNA decay in human cells.