RNA Helicase on Maragkakis Lab

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

Mon, 01 May 2023 00:00:00 +0000

Summary

This study shows that MOV10, an RNA helicase with roles in the piRNA pathway, acts as a dosage-dependent restriction factor for LINE1 retrotransposons in mice. Reduction of MOV10 levels leads to increased LINE1 retrotransposition, implicating MOV10 in genome defense against mobile elements.

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing

Sun, 15 Mar 2015 00:00:00 +0000

Summary

This study demonstrates that MOV10L1, a germline-specific RNA helicase, directly binds to piRNA precursors and is required for their processing into mature piRNAs. MOV10L1 acts upstream of Piwi proteins in the piRNA biogenesis pathway, providing mechanistic insight into piRNA production.