TDP-43 on Maragkakis Labhttp://maragkakislab.com/tags/tdp-43/Recent content in TDP-43 on Maragkakis LabHugoen-usFri, 26 Jan 2024 00:00:00 +0000Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTDhttp://maragkakislab.com/publications/2024-tdp43-mis-spliced-proteins/Fri, 26 Jan 2024 00:00:00 +0000http://maragkakislab.com/publications/2024-tdp43-mis-spliced-proteins/<h2 id="summary">Summary</h2> <p>This study demonstrates that loss of TDP-43 function leads to widespread cryptic splicing events that produce novel protein isoforms not normally expressed in healthy cells. These de novo proteins may contribute to the pathogenesis of ALS and FTD by triggering immune responses or impairing cellular functions.</p>