Topoisomerase on Maragkakis Labhttp://maragkakislab.com/tags/topoisomerase/Recent content in Topoisomerase on Maragkakis LabHugoen-usThu, 03 Apr 2025 00:00:00 +0000Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell developmenthttp://maragkakislab.com/publications/2025-topoisomerase-3b-pirna/Thu, 03 Apr 2025 00:00:00 +0000http://maragkakislab.com/publications/2025-topoisomerase-3b-pirna/<h2 id="summary">Summary</h2> <p>This study identifies Topoisomerase 3β as a factor that facilitates piRNA biogenesis, with loss of TOP3B leading to reduced piRNA production, derepression of transposable elements, and impaired germ cell development. The findings reveal a novel role for a DNA/RNA topoisomerase in small RNA biology.</p>