Transcription on Maragkakis Labhttp://maragkakislab.com/tags/transcription/Recent content in Transcription on Maragkakis LabHugoen-usSun, 28 Jul 2024 00:00:00 +0000Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aginghttp://maragkakislab.com/publications/2024-dna-hydroxymethylation-aging/Sun, 28 Jul 2024 00:00:00 +0000http://maragkakislab.com/publications/2024-dna-hydroxymethylation-aging/<h2 id="summary">Summary</h2> <p>This study reveals that 5-hydroxymethylcytosine (5hmC) enrichment in gene bodies acts as an epigenetic mechanism that constrains the amplitude of transcriptional changes occurring during aging. Genes with high 5hmC show attenuated age-related expression changes, identifying DNA hydroxymethylation as a regulator of transcriptional stability in aging tissues.</p>