The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

Summary

This study shows that MOV10, an RNA helicase with roles in the piRNA pathway, acts as a dosage-dependent restriction factor for LINE1 retrotransposons in mice. Reduction of MOV10 levels leads to increased LINE1 retrotransposition, implicating MOV10 in genome defense against mobile elements.