Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts

Cell Reports · June 2026 · Full text

Olinger B, Anerillas C, Herman AB, ... , Qi YA, Ferrucci L, Gorospe M, Basisty N

SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent primary cell types

Molecular Cell · June 2026 · Full text

Anerillas C, Altes G, Gresova K, ... , Herman AB, Maragkakis M, Basisty N, Gorospe M

Transcript-guided targeted cell enrichment for scalable single-nucleus RNA sequencing

Cell Genomics · March 2026 · Full text

Liao A, Zhang Z, Sziraki A, ... , Lee J, Maragkakis M, Zhou W, Cao J

Senescence: An overlooked VSMC phenotype and therapeutic opportunity?

Arteriosclerosis, Thrombosis, and Vascular Biology · November 2025 · Full text

Herman AB, Gresova K, Maragkakis M, Autieri MV

Viral Infection Induces Alzheimer's Disease-Related Pathways and Senescence in iPSC-Derived Neuronal Models

bioRxiv (preprint) · June 2025 · Full text

Hribkova H, Pospisilova V, Amruz Cerna K, ... , Vajrychova M, Sheardova K, Ruzek D, Bohaciakova D

Cell-specific RNA isoform remodeling in the aging mouse brain

bioRxiv (preprint) · June 2025 · Full text

Rehman A, Duffy M, Belair C, ... , Malla S, Sen P, Cookson MR, Maragkakis M

Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter

Nature Communications · April 2025 · Full text

Wang L, Cui C-Y, Lee CT, ... , Biragyn A, Benjamini D, Maragkakis M, Sen P

Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development

Cell Reports · April 2025 · Full text

Lee SK, Shen W, Wen W, ... , Gainetdinov I, Sharov A, Maragkakis M, Wang W

Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

eLife · December 2024 · Full text

Dar SA, Malla S, Martinek V, ... , Khandeshi AJ, Martindale JL, Belair C, Maragkakis M

Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype

Molecular Cell · November 2024 · Full text

Payea MJ, Dar SA, Anerillas C, ... , Banskota N, Abdelmohsen K, Gorospe M, Maragkakis M

Deep learning and direct sequencing of labeled RNA captures transcriptome dynamics

NAR Genomics and Bioinformatics · September 2024 · Full text

Martinek V, Martin J, Belair C, ... , Payea MJ, Malla S, Alexiou P, Maragkakis M

Gene body DNA hydroxymethylation restricts the magnitude of transcriptional changes during aging

Nature Communications · July 2024 · Full text

Occean JR, Yang N, Sun Y, ... , Maragkakis M, de Cabo R, Sidoli S, Sen P

Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD

Science Translational Medicine · January 2024 · Full text

Seddighi S, Qi YA, Brown AL, ... , Maragkakis M, Petrucelli L, Fratta P, Ward ME

Differential Poly(A) Tail Length Analysis Using Nanopore Sequencing

Deadenylation: Methods and Protocols (Springer) · October 2023 · Full text

Dar SA, Malla S, Belair C, Maragkakis M

RNA-mediated control of protein translation under stress

Antioxidants & Redox Signaling · July 2023 · Full text

Payea MJ, Dar SA, Malla S, Maragkakis M

Biology of Stress Responses in Aging

Aging Biology · June 2023 · Full text

Maragkakis M, Malla S, Hatzoglou M, ... , de Cabo R, Wilson DM 3rd, Ferrucci L, Gorospe M

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

PLoS Genetics · May 2023 · Full text

Guan Y, Gao H, Leu NA, ... , Kang Z, Mourelatos Z, Liang G, Wang PJ

SamQL: A Structured Query Language and filtering tool for the SAM/BAM file format

BMC Bioinformatics · October 2021 · Full text

Lee CT-Y, Maragkakis M

TERA-Seq: True end-to-end sequencing of native RNA molecules for transcriptome characterization

Nucleic Acids Research · August 2021 · Full text

Ibrahim F, Oppelt J, Maragkakis M, Mourelatos Z

Modulation of Aub-TDRD interactions elucidates piRNA amplification and germplasm formation

Life Science Alliance · March 2021 · Full text

Vrettos N, Maragkakis M, Alexiou P, ... , Ibrahim F, Palmieri D, Kirino Y, Mourelatos Z