Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter

Nature Communications · April 2025

Wang L, Cui C-Y, Lee CT, Bodogai M, Yang N, Shi C, Irfanoglu MO, Occean JR, Afrin S, Sarker N, McDevitt RA, Lehrmann E, Abbas S, Banskota N, Fan J, De S, Rapp P, Biragyn A, Benjamini D, Maragkakis M, Sen P

Summary

Spatial transcriptomics profiling of the aging mouse brain reveals that inflammatory gene expression changes during aging are not uniformly distributed but originate preferentially in white matter regions. The findings provide a spatially resolved map of the aging brain transcriptome and identify candidate cellular drivers of neuroinflammation.

Summary#

Summary