Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development

Cell Reports · April 2025

Lee SK, Shen W, Wen W, Joo Y, Xue Y, Park A, Qiang A, Su S, Zhang T, Zhang M, Fan J, Zhang Y, De S, Gainetdinov I, Sharov A, Maragkakis M, Wang W

Summary

This study identifies Topoisomerase 3β as a factor that facilitates piRNA biogenesis, with loss of TOP3B leading to reduced piRNA production, derepression of transposable elements, and impaired germ cell development. The findings reveal a novel role for a DNA/RNA topoisomerase in small RNA biology.

Summary#

Summary