SenCat: Redefining human cell senescence through multiomic profiling of multiple senescent primary cell types

Molecular Cell · June 2026

Anerillas C, Altes G, Gresova K, Tsitsipatis D, Mazan-Mamczarz K, Banarjee R, Cunningham ASG, Altés G, Salamini-Montemurri M, Yang JH, Munk R, Rossi M, Piao Y, Olinger B, Strassheim Q, Martindale JL, Fan J, Cui CY, De S, Rutherford DV, Abdelmohsen K, de Cabo R, Herman AB, Maragkakis M, Basisty N, Gorospe M

Summary

SenCat is a comprehensive multiomic atlas of human cell senescence generated by profiling multiple primary cell types induced to senescence through distinct triggers. Integrated analysis of transcriptome, epigenome, and proteome data across cell types and senescence inducers redefines the core features of the senescent state and identifies cell-type-specific and universal senescence signatures.

Summary#

Summary