Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts

Cell Reports · June 2026

Olinger B, Anerillas C, Herman AB, Tsitsipatis D, Banarjee R, Tanaka T, Candia J, Maragkakis M, Bandinelli S, Walker KA, Simonsick EM, Qi YA, Ferrucci L, Gorospe M, Basisty N

Summary

This study profiles cell-type-specific senescence signatures in circulating blood cells from human longitudinal cohorts and shows that these signatures track distinct dimensions of health status and aging trajectories. The findings establish circulating senescence signatures as high-resolution biomarkers of biological aging with potential utility for monitoring healthspan in humans.

Summary#

Summary